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National Institute of Diabetes and Digestive and Kidney Diseases

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The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), of the U.S. National Institutes of Health, conducts and supports research on many of the most serious diseases affecting public health. The Institute supports much of the clinical research on the diseases of internal medicine and related subspecialty fields as well as many basic science disciplines.

The Institute's Division of Intramural Research encompasses the broad spectrum of metabolic diseases—including diabetes, obesity, inborn errors of metabolism, endocrine disorders, disorders of mineral metabolism—as well as digestive and liver diseases, nutrition, urology and renal disease, and hematology. Basic research studies include biochemistry, biophysics, nutrition, pathology, histochemistry, bioorganic chemistry, physical chemistry, chemical and molecular biology, and pharmacology.

NIDDK extramural research is organized into four divisions: Diabetes, Endocrinology and Metabolic Diseases; Digestive Diseases and Nutrition; Kidney, Urologic and Hematologic Diseases; and Extramural Activities.

The Institute supports basic and clinical research through investigator-initiated grants, program project and center grants, and career development and training awards. The NIDDK also supports research and development projects and large-scale clinical trials through contracts.


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[edit] NIDDK Office of the Director

Griffin P. Rodgers, M.D., M.B.A, M.A.C.P. is currently the director of the NIDDK. Dr. Rodgers also serves as deputy director of NIDDK (since 2001) and as chief of NIDDK's Molecular and Clinical Hematology Branch (since 1998).

Dr. Rodgers received his undergraduate, graduate and medical degrees from Brown University in Providence, Rhode Island. He also has a master's degree in business administration, with a focus on the business of medicine from Johns Hopkins University. He did his residency and chief residency in internal medicine at Barnes Hospital, and the St. Louis VA Hospital, respectively, Washington University School of Medicine in St. Louis, Missouri. His fellowship training in hematology/oncology was in a joint program of the NIH with George Washington University and the Washington Veterans Administration Medical Center.

Dr. Rodgers is widely recognized for his contributions to the development of the first effective — and now FDA approved — therapy for sickle cell anemia. He has served as the principal investigator in clinical trials to elevate pharmacologically fetal hemoglobin to counteract the deleterious molecular and cellular effects present in the red cells of these patients. Dr. Rodgers' basic research has focused on understanding the molecular basis of how these drugs induce gamma-globin gene expression and on lineage-specific differentiation of hematopoietic stem cells. He was honored for his research with the 1998 Richard and Hinda Rosenthal Foundation Award and the 2000 Arthur S. Fleming Award, among others. He has published over 150 original research articles, reviews, and book chapters and has edited two books.

Dr. Rodgers served as governor to the American College of Physicians for the Department of Health and Human Services and is a member of the American Society of Hematology, the American Society of Clinical Investigation, and the Association of American Physicians. He is the chair of the Hematology Subspecialty Board and is a member of the ABIM Board of Directors.

[edit] Division of Intramural Research (DIR)

The Division of Intramural Research conducts research and training within the Institute's laboratories and clinical facilities in Bethesda, Maryland, and at the Phoenix Epidemiology and Clinical Research Branch in Arizona.

The Division has 12 Branches and 10 Laboratories that cover a wide range of research areas. In addition, there is a section on veterinary sciences, a section on biological chemistry, the Office of Technology Transfer, the Office of Fellow Recruitment and Career Development, and an Administrative Management Branch. Six core laboratories provide scientific support services to investigators.

The Intramural Branches engage in both basic and clinical research on diabetes, bone metabolism, endocrinology, obesity, hematology, digestive diseases, kidney diseases, kidney transplantation and genetics. Additionally, the Phoenix Branch develops and applies epidemiologic and genetic methods to the study of diabetes and obesity. The tenth branch addresses mathematical modeling of biological problems.

The Laboratories are engaged in fundamental research related to the institute's mission in the fields of molecular biology, structural biology, chemistry, cell biology, pharmacology, chemical physics, biochemistry, neuroscience, and developmental biology, and mathematical modeling of biological problems.

The Laboratory Animal Science section provides research animal support and collaboration for institute research programs. The six core laboratories provide services to interested NIDDK scientists in the areas of proteomics and mass spectrometry, microarray, chemical biology, mouse metabolism/transgenic support, biotechnological support, and knockout mice.


[edit] Division of Extramural Activities (DEA)

The Division of Extramural Activities (DEA) is responsible for coordinating the receipt, referral and scientific review of extramural research applications and proposals before funding, and for the processing of awards for grants, cooperative agreements and contracts. It logs in, assigns and internally distributes all extramural applications and proposals received by the NIDDK, and conducts scientific and technical peer review for grant applications and contract proposals requiring special programmatic consideration. The DEA also manages an acquisitions and general contracting service center that services NIDDK and several other NIH Institutes/Centers as well. The DEA also coordinates the Institute’s Committee Management Activities and the meetings of the National Diabetes and Digestive and Kidney Diseases Advisory Council. Finally, the DEA performs and coordinates programmatic analysis and evaluation activities.

Organizationally the Division has three primary functional components: The Grants Management Branch is the focal point for all business-related activities associated with the negotiation, award, and administration of grants and cooperative agreements within the NIDDK.

The Scientific Review Branch coordinates the initial scientific peer review of applications submitted in response to Request for Applications (RFAs), training and career awards, program projects, multi-center clinical trials and research contracts, including Loan Repayment Program applications. Most R01s, R21s, Fellowship and SBIR grant applications are reviewed in the Center for Scientific Review.

The Office of Acquisitions plans, organizes, directs, awards, and administers a comprehensive acquisition program for three Institutes and one Center: NIDDK, the National Institute of Child Health and Human Development (NICHD); the National Institute on Alcohol Abuse and Alcoholism (NIAAA); and the John E. Fogarty International Center (FIC).


[edit] Division of Diabetes, Endocrinology and Metabolic Diseases (DDEM)

The DEMD supports research and research training related to diabetes mellitus, endocrinology, and metabolic diseases including cystic fibrosis. In addition, DEMD leads the administration of the Trans-NIH Diabetes Program and coordinates federally supported diabetes-related activities.


[edit] Division of Digestive Diseases and Nutrition (DDDN)

This division supports research related to liver and biliary diseases, pancreatic diseases, gastrointestinal diseases, including neuroendocrinology, motility, immunology, and digestion in the GI tract, nutrient metabolism, obesity, eating disorders, and energy regulation. The division provides leadership in coordinating activities related to digestive diseases and nutrition throughout the NIH and with various other Federal agencies.


[edit] Division of Kidney, Urologic and Hematologic Diseases (DKUH)

The division supports research on diseases of the kidney, genitourinary tract, and blood and blood-forming organs, and on the fundamental biology relevant to these organ systems. It funds training and professional development of investigators in disciplines critical for research in these areas.

[edit] Health Education and Information Services

National Diabetes Information Clearinghouse (NDIC)
National Digestive Diseases Information Clearinghouse (NDDIC)
National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC)

The three clearinghouses serve as information resources for patients, the public, and health professionals concerned with diabetes, digestive diseases, and kidney and urologic diseases. Each was authorized by Congress to increase knowledge and understanding about these areas through the effective dissemination of information. The NDIC was authorized by Congress in 1976, the NDDIC in 1980, and the NKUDIC in 1987.

The clearinghouses answer inquiries; develop, print and distribute publications; and work closely with professional and patient-advocacy organizations and U.S. Government agencies to coordinate informational resources about diabetes, digestive diseases, and kidney and urologic diseases.

The clearinghouses also develop and maintain a free, online bibliographic database of reference materials, audiovisuals, educational materials, and “fugitive” literature in its Reference Collection, as well as an image library of free non-copyrighted images, and linkages to relevant interactive resources.

The clearinghouses provide two campaigns to increase awareness and action for people with underdiagnosed or undertreated conditions: celiac disease and bladder control issues in women.

Addresses are:
NDIC, 1 Information Way, Bethesda, Maryland 20892-3560, phone: 1-800-860-8747;
NDDIC, 2 Information Way, Bethesda, Maryland 20892-3570, phone: 1-800-891-5389;
NKUDIC, 2 Information Way, Bethesda, Maryland 20892-3580, phone: 1-800-891-5390.

National Diabetes Education Program (NDEP)
The NDEP, co-sponsored by the NIDDK and the Centers for Disease Control and Prevention (CDC), is focused on improving the treatment and outcomes for people with diabetes, promoting early diagnosis, and ultimately preventing the onset of diabetes. The goal of the program is to reduce the morbidity and mortality associated with diabetes through public awareness and education activities targeted to the general public, especially those with at risk for type 2 diabetes, people with diabetes and their families, health care providers, and policy makers and payers. These activities are designed to 1) increase public awareness that diabetes is a serious, common, costly, and controllable disease that has recognizable symptoms and risk factors; 2) encourage people with diabetes, their families, and their social support systems to take diabetes seriously and to improve practice of self-management behaviors; 3) reduce disparities in health in racial and ethnic populations disproportionately affected by diabetes and 4) alert health care providers to the seriousness of diabetes, effective strategies for its prevention and control, and the importance of a team care approach to helping patients manage the disease. Toward these ends, the NDEP develops partnerships with organizations concerned about diabetes and the health care of its constituents.

Contact information for the program is as follows:
1 Diabetes Way
Bethesda, Maryland 20892-3600
Phone 800-438-5383.


National Kidney Disease Education Program (NKDEP)
The NKDEP addresses the growing problem of kidney disease in this country and aims to reduce the morbidity and mortality caused by kidney disease and its complications. The program is dedicated to raising awareness of the seriousness of kidney disease and its risk factors, the importance of testing those at high risk, and the availability of treatment to prevent or slow the progression of kidney disease to kidney failure.

Contact information for the program is as follows:
National Kidney Disease Education Program
3 Kidney Information Way
Bethesda, MD 20892
Toll free 1-866-4-KIDNEY (1-866-454-3639)
Fax: 301-402-8182



[edit] Weight-control Information Network

The WIN is a national information service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH). WIN was established in 1994 to provide health professionals and consumers with science-based information on obesity, weight control, and nutrition. WIN has also developed the Sisters Together: Move More, Eat Better Media program that encourages Black women 18 and over to maintain a healthy weight by becoming more physically active and eating healthier foods.

Contact information for WIN is as follows:
The Weight-control Information Network
1 WIN Way, Bethesda, Maryland 20892-3665
Toll-free number: 1-877-946-4627
Fax: 202-828-1028

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Saturday, April 12, 2008

Diabetes Prevention
Diabetes prevention is proven, possible, and powerful। Studies show that people at high risk for type 2 diabetes can prevent or delay the onset of the disease by losing 5 to 7 percent of their body weight. You can do it by eating healthier and getting 30 minutes of physical activity 5 days a week. In other words: you don't have to knock yourself out to prevent diabetes. The key is: small steps that lead to big rewards. Learn more about your risk for developing type 2 diabetes and the small steps you can take to delay or prevent the disease and live a long, healthy life.
Things to Do Every Day for Good Diabetes Care
Follow the healthy eating plan that you and your doctor or dietitian have worked out.
Be active a total of 30 minutes most days. Ask your doctor what activities are best for you.
Take your medicines as directed.
Check your blood glucose every day. Each time you check your blood glucose, write the number in your record book.
Check your feet every day for cuts, blisters, sores, swelling, redness, or sore toenails.
Brush and floss your teeth every day.
Control your blood pressure and cholesterol.
Don’t smoke.
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Things for Your Health Care Provider to Look at Every Time You Have a Checkup
Your blood glucose records
Show your records to your health care provider.
Tell your health care provider if you often have low blood glucose or high blood glucose.
Your weight
Talk with your health care provider about how much you should weigh.
Talk about ways to reach your goal that will work for you.
Your blood pressure
The goal for most people with diabetes is less than 130/80.
Ask your health care provider about ways to reach your goal.
Your diabetes medicines plan
Talk to your health care provider about any problems you have had with your diabetes medicines.
Your feet
Ask your health care provider to check your feet for sores.
Your plan for physical activity
Talk with your health care provider about what you do to stay active.
Your meal plan
Talk about what you eat, how much you eat, and when you eat.
Your feelings
Ask your health care provider about ways to handle stress.
If you are feeling sad or unable to cope with problems, ask about how to get help.
Your smoking
If you smoke, talk with your health care provider about how you can quit.
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Things for You or Your Health Care Provider to Do at Least Once or Twice a Year
A1C test
Have this blood test at least twice a year (See How can I find out what my average blood glucose is?) Your result will tell you what your average blood glucose level was for the past 2 to 3 months.
Blood lipid (fats) lab tests
Get a blood test to check your
total cholesterol—aim for below 200
LDL—aim for below 100
HDL—men: aim for above 40; women: aim for above 50
triglycerides—aim for below 150
These test results will help you plan how to prevent heart attack and stroke.
Kidney function tests
Once a year, get a urine test to check for protein. At least once a year, get a blood test to check for creatinine. The results will tell you how well your kidneys are working.
Dilated eye exam
See an eye care professional once a year for a complete eye exam.
Dental exam
See your dentist twice a year for a cleaning and checkup.
Foot exam
Ask your health care provider to check your feet to make sure your foot nerves and your blood circulation are OK.
Flu shot
Get a flu shot each year.
Pneumonia vaccine
Get one; if you’re over 64 and your shot was more than 5 years ago, get one more.
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How to Use the Daily Diabetes Record Page
Use copies of the record page to keep track of blood glucose checks, medicines, and notes about things that affect your blood glucose. Make one copy of the record page for each week. This record will help you see whether your diabetes plan is working. Review your record with your health care providers.
Blood Glucose Checks
Talk with your health care provider and decide on the best times to check blood glucose. You may be checking blood glucose before meals, after meals, or at bedtime. Write when to check here:
___________________________________________ ___________________________________________ ___________________________________________ ___________________________________________ ___________________________________________ ___________________________________________ ___________________________________________
If needed, draw a line in the boxes under "Breakfast," "Lunch," and "Dinner" to make room for blood glucose check results before and after a meal, like this example:
See What should my blood glucose numbers be? for information about target blood glucose levels.
Medicines
Under the heading marked "Medicine," write the names of your diabetes medicines and the amounts taken.
Notes
Write down things that affect your blood glucose level. Some examples are
eating more or less than usual
forgetting to take your diabetes medicine
exercising—write down what kind and for how long
being sick or upset about something—being under stress
going to a social event or other special event, or being on vacation
Daily Diabetes Record Page
View and print a daily diabetes record page.
My Health Care Team Members

Name and Address
Phone Number
Doctor



Diabetes dietitian educator


Diabetes nurse educator


Eye care professional



Dentist



Foot doctor



Pharmacist



Counselor

3 Comments:

At April 14, 2008 at 11:26 PM , Anonymous Anonymous said...

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At April 17, 2008 at 7:48 AM , Anonymous Anonymous said...

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